Get this from a library models of calcium signalling genevive dupont m falcke vivien kirk james sneyd this book discusses the ways in which mathematical computational and modelling methods can be used to help understand the dynamics of intracellular calcium the concentration of free intracellular . Even though there are many models of calcium signalling these behave in essentially similar ways in that they model the cicr process in some way and give rise to oscillations and waves . Calcium oscillations physiological mechanisms the resting state at rest the concentration of calcium in the cell cytoplasm is low around 30 nm while outside the cell and in the internal compartments such as the endoplasmic reticulum er sarcoplasmic reticulum sr and mitochondria it is orders of magnitude higher these concentration gradients are maintained in part by calcium atpase . This book is entirely focused on the modelling aspects how quantitative models of calcium signalling are constructed and how they can help build bridges between seemingly unrelated observations the book is intended for people who are familiar with the basic theory of differential equations
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